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王文教授
2016-06-03 08:37   审核人:

王文,现为西北工业大学二级教授、博导,国家杰出青年基金获得者,国家创新研究群体首席科学家。


1989年毕业于武汉大学生物系, 获学士学位。 

1992年在中科院获得硕士学位,1996年获得博士学位。 

1997年8月至2002年7月为美国芝加哥大学博士后暨研究助理。

 

 

 

长期来一直进行进化基因组学研究,目前已经在Science, Nature, Nature Genetics, Nature Biotechnology, Nature Communications, Nature Review Genetics, PNAS, Genome Research, Plant Cell, Genetics, Trends in Genetics, Genome Biology等重要学术杂志上发表多篇论文,其中第一和通讯(含共同通讯)作者SCI论文43篇,合作发表SCI 30多篇。迄今论文被引用共6500 多次,H index为36。2004年获得国家杰出青年基金。2004年“新世纪百千万人才工程国家级首批入选者”。2007年和2012年作为首席科学家分别获得 “973”项目的支持。2012年获得“国家自然科学二等奖”(第一完成人)。是中国遗传学会常务理事,中国遗传学会动物遗传专业委员会主任,《中国科学.生命科学》编委。

 

发表论文 

通讯作者和第一作者代表性SCI论文 (*通讯作者)

1. Li X, Fan D, Zhang W, Liu G, Zhang L, Zhao L, Fang X, Chen L, Dong Y, Chen Y1, Ding Y, Zhao R, Feng M, Zhu Y, Feng Y, Jiang X, Zhu Y, Xiang H, Feng X, Li S, Wang J, Zhang G, Kronforst MR, Wang W*. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nature Communications (2015), 6: 8212. DOI 10.1038.

2. Zhou Z, Jiang Y, Wang Z, Gou Z, Lyu L, Li W, Yu Y, Shu L, Zhao Y, Ma Y, Fang C, Shen Y, Liu T, Li C, Li Q, Wu M, Wang M, Wu Y, Dong Y, Wan W, Wang X, Ding Z, Gao Y, Xiang H, Zhu B, Lee S-H, Wang W*, Tian Z*. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature Biotechnology (2015), 33 (4): 408-414.

3. Jiang Y, Xie M, Chen WB, Talbot R, Maddox JF, Faraut T, Wu CH, Muzny DM, Li YX, Zhang WG, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SMJ, Adelson DL, Bian C, Cam GR, Chen YL, Cheng SF, DeSilva U, Dixen K, Dong Y, Fan GY, Franklin IR, Fu SY, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang GD, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu WQ, Liu X, Lu CX, Lv T, Mathew T, McWilliam S, Menzies M, Pan SK, Robelin D, Servin B, Townley D, Wang WL, Wei B, White SN, Yang XH, Ye C, Yue YJ, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W*, Dalrymple BP. The sheep genome illuminates biology of the rumen and lipid metabolism. Science (2014) 344: 1168-73.

4. Lyu J, Zhang SL, Dong Y, He WM, Zhang J, Deng X, et al, Wang W* Analysis of elite variety tag SNPs reveals an important allele in upland rice, Nature Communications (2013) 4:2138.

5. Dong Y, Xie M, Jiang Y, Xiao NQ, Du XY, Zhang WG, Tosser-Klopp G, Wang JH, Yang S, Liang J, Chen WB, Chen J, Zeng P, Hou Y, Bian C, Pan SK, Li YX, Liu X, Wang WL, Servin B, Sayre B, Zhu B, Sweeney D, Moore R, Nei WH, Shen YY, Zhao RP, Zhang GJ, Li JQ, Faraut T, Womack J, Zhang YP, Kijas J, Cockett N, Xu X, Zhao SH, Wang J, Wang W*. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nature Biotechnology (2013) 31: 135-141.

6. Ding Y, Zhou Q, Wang W* Origins of New Genes and Evolution of their Novel Functions. Annual Review of Ecology, Evolution, and Systematics (2012) 43:345-363(invited review).

7. Zhan ZB, Ding Y, Zhao RP, Zhang Y, Yu HJ, Zhou Q, Yang S, Xiang H, Wang W*. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan. Molecular Biology and Evolution (2012). 29(5): 1407-1416.

8. Xu X, Liu X, Ge S, Jensen D J, Hu FY, Li X, Dong Y, Gutenkunst NR, Fang L, Huang Li, Li JX, He WM , Zhang GJ, Zheng XM, Zhang FM,Li YR, Yu C, Kristiansen K, Zhang XQ, Wang J, Wright M, McCouch S, Nielsen R, Wang J, Wang W*. Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nature Biotechnology (2012) 30: 105-111.

9. Ding Y, Zhao L, Yang S, Jiang Y, Chen Y, Zhao R, Zhang Y, Zhang G, Dong Y, Yu H, Zhou Q, Wang W*. A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-linked Male Fertility Genes. PLoS Genetics (2010) 6 (12): e1001255. IF= 9.543.

10. Li D, Dong Y, Jiang H, Cai J, Wang W*. A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research (2010) 20:408-420.

11. Xiang H, Zhu JD, Chen Q, Dai FY, Li X, Li MW, Zhang HY, Zhang GJ, Li D, Dong Y, Zhao L, Lin Y, Cheng DJ, Yu J, Sun JF, Zhou XY, Ma KL, He YH, Zhao YX, Guo SC, Ye MZ, Guo GW, Li YR, Li RQ, Zhang XQ, Ma LJ, Kristiansen K, Guo QH, Jiang JH, Beck S, Xia QY*, Wang W*, Wang J. Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. Nature Biotechnology (2010) 28: 516-520.

12. Li X, Zhao L, Jiang H, Wang W* Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes. J. Mol. Evol. 68 (2009): 56-65.

13. Zhou Q, Wang J, Huang L, Nie W, Wang J, Liu Y, Zhao X, Yang F, Wang W* Neo-sex chromosomes in the black muntjac recapitulate incipient evolution of mammalian sex chromosomes. Genome Biology 9 (2008): R98.

14. Zhou Q, Zhang G, Xu S, Zhao R, Li X, Ding Y, Wang W* On the origin of new genes in Drosophila. Genome Research 18 (2008):1446-1455.

15. Jiang H, Guan W, Pinney D, Wang W*, Gu Z Relaxation of yeast mitochondrial functions after whole genome duplication. Genome Research 18 (2008):1466-1471.

16. Cai J, Zhao R, Jiang H, Wang W* De novo origination of a new protein-coding gene in Sacchoramyces cerevisiae. Genetics 179 (2008): 487-496.

17. Yang S, Arguello JR, Li X, Ding Y, Zhou Q, Chen Y, Zhang Y, Zhao R, Brunet F, Peng L, Long M*, Wang W* Repetitive elements-mediated recombination as a mechanism for new gene origination in Drosophila. PLoS Genetics 4(2008):e3.

18. Li X, Liang J, Yu H, Su B, Xiao C, Shang YF, Wang W* Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23 (2007): 427-431.

19. Wang W, Zheng H, Fan C, Li J, Shi J, Cai Z, Zhang G, Liu D, Zhang J, Vang S, Lu Z, Wong GKS, Long M, Wang J High rate of chimeric gene origination by retroposition in plant genomes. Plant Cell 18 (2006):1797-1802.

20. Yu H, Jiang H, Zhou Q, Yang J, Cun Y, Su B, Xiao C, Wang W* Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. Hum. Mol. Genet. 15 (2006):1870-1875.

21. Arguello JR, Chen Y, Yang S, Wang W*, Long M. Origination of an X-linked Testes Chimeric Gene by Illegitimate Recombination in Drosophila. PLoS Genetics 2 (2006): 745-754.

22. Yu H, Zhao X, Su B, Li D, Xu Y, Luo S, Xiao C, Wang W*. Expression of NF1 Pseudogenes. Human Mutation (2005) 26: 487-488.

23. Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W* . Variety of Antimicrobial Peptides in the Bombina maxima Toad and Evidence of their Rapid Diversification. European Journal of Immunology (2005) 35: 1220-1229.

24. Wang W *et al., Origin and Evolution of New Exons in Rodents. Genome Res. 15 (2005): 1258-1264.

25. Wang W, Yu H, Long M Duplication-degeneration as a mechanism of gene fission and the origin of new genes in Drosophila. Nature Genetics 36 (2004):523-527.

27. Wang W, Thornton K, Emerson JJ, Long M*. Nucleotide variation and recombination along the fourth chromosome in Drosophila simulans. Genetics (2004)166: 1783-1794.

28. Wang W, Brunet FG, Nevo E, Long M Origin of Sphinx, a young chimeric RNA gene in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 99 (2002): 4448-4453.

29. Wang W, Thornton K, Berry A, Long M Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science 295 (2002): 134-137.

30. Wang W, Zhang J, Alvarez C, Llopart A, Long M 2000 The origin of the jingwei gene and the complex modular structure of its parental gene, yellow emperor, in D. melanogaster. Mol Biol. Evol. 17 (2000): 1294-1301.

31. Wang W, Lan H Rapid and parallel chromosomal number reductions in muntjac deer inferred from mitochondrial DNA phylogeny. Mol. Biol. Evol. 17 (2000): 1326-1333.

与他人合作的重要论文:

32. Ma Y, Dai X, Xu Y, Luo W, Zheng X; Zeng D, Pan Y, Lin X, Liu H, Zhang D, Xiao J, Guo X, Xu S, Niu Y, Jin J, Zhang H, Xu X, Li L, Wang W, Qian Q, Ge S, Chong K. COLD1 Confers Chilling Tolerance in Rice. Cell (2015), 160 (6):1209-1221; 10.1016/j.cell.2015.01.046 MAR 12.

33. Sun H, Qian Q, Wu K, Luo J, Wang S, Zhang C, Ma Y, Liu Q, Huang X, Yuan Q, Han R, Zhao M, Dong G, Guo L, Zhu X, Gou Z, Wang W, Wu Y, Lin H, Fu X. Heterotrimeric G proteins regulate nitrogen-use efficiency in rice. Nature Genetics, 2014, 46(6): 652-656.

34. Hou Y, Song L, Zhu P, Zhang B, Tao Y, Xu X, Li F, Wu K, Liang J, Shao D, Wu H, Ye X, Ye C, Wu R, Jian M, Chen Y, Xie W, Zhang R, Chen L, Liu X, Yao X, Zheng H, Yu C, Li Q, Gong Z, Mao M, Yang X, Yang L, Li J, Wang W, Lu Z, Gu N, Laurie G, Bolund L, Kristiansen K, Wang J, Yang H, Li Y, Zhang X, Wang J. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 148(5): 873-85. IF= 32.403.

35. Yanga S,Yuana Y,Wanga L, Lia J, Wang W, Liua H, Chena JQ, Hurstc LD, Tiana D&. Great majority of recombination events in Arabidopsis are gene conversion events. Proc. Natl. Acad. Sci. USA 109(2012): 20992–20997.

36. Xia QY, Guo YR, Zhang Z, Li D , Xuan ZL, Li Z, Dai F, Li YR, Cheng DJ, Li RQ, Cheng TC, Jiang T, Becquet C, Xu X, Liu C, Zha XF, FanW, Lin Y, Shen YH, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu HF, Yu C, Zhang GJ, Li J, Cao JJ, Liu S, He NJ, Zhou Y, Liu H, Zhao J, Ye C, Du ZH, Pan GQ, Zhao AC, Shao HJ , Zeng W, Wu P, Li CF, Pan MH, Li JJ, Yin XY, Li DW, Wang J, Zheng HS , Wang W, Zhang XQ, Li SG, Yang HM, ] Lu C, Nielsen R, Zhou ZY , Wang J, Xiang ZG, Wang J. Complete resequencing of 40 Genomes reveals domestication events and genes in Silkworm (Bombyx). Science (2009) 326: 433-436.

37. Xia QY, Zhou ZY, Lu C, Cheng DJ, Dai FY, Li B, Zhao P, Zha XF, Cheng TC, Chai CL, Pan GQ, Xu JS, Liu C, Lin Y, Qian JF, Hou Y, Wu ZL, Li GR, Pan MH, Li CF, Shen YH, Lan XQ, Yuan LW, Li T, Xu HF, Yang GW, Wan YJ, Zhu Y, Yu MD, Shen WD, Wu DY, Xiang ZH, Yu J, Wang J, Li RQ, Shi JP, Li H, Li GY, Su JN, Wang XL, Li GQ, Zhang ZJ, Wu QF, Li J, Zhang QP, Wei N, Xu JZ, Sun HB, Dong L, Liu DY, Zhao SL, Zhao XL, Meng QS, Lan FD, Huang XG, Li YZ, Fang L, Li CF, Li DW, Sun YQ, Zhang ZP, Yang Z, Huang YQ, Xi Y, Qi WH, He DD, Huang HY, Zhang XW, Wang ZQ, Li WJ, Cao YZ, Yu YP, Yu H, Li JH, Ye JH, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li ST, Ni PX, Zhang JG, Zhang Y, Zheng HK, Mao BY, Wang W, Ye C, Li SG, Wang J, WongGKS, Yang HM. Silkworm Genome Sequencing Consortium. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2005).306: 1937-1940.

38. Yu J, Wang J, Lin W, Li SG, Li H, Zhou J, Ni PX, Dong W, Hu SN, Zeng CQ, Zhang JG, Zhang Y, Li RQ, Xu ZY, Li ST, Li XR, Zheng HK, Cong LJ, Lin L, Yin JN, Geng JN, Li1 GY, Shi JP, Liu J, Lv H, Li J, Wang J , Deng YJ, Ran LH, Shi XL, Wang XY, Wu QF, Li CF, Ren XY, Wang JQ, Wang XL, Li DW, Liu DY, Zhang XW, Ji ZD, Zhao WM, Sun YQ, Zhang ZP, Bao JY, Han YJ, Dong LL, Ji J, Chen P, Wu S, Liu JS, Xiao Y, Bu DB, Tan JL, Yang L, Ye C, Zhang ZF, Xu JY, Zhou Y, Yu YP, Zhang B, Zhuang SL, Wei HB, Liu B, Lei M, Yu H, Li YZ, Xu H, Wei SL, He XM, Fang LJ, Zhang ZJ, Zhang YZ, Huang XG, Su ZX, Tong W, Li JH, Tong ZZ, Li SL, Ye J, Wang LS, Fang L, Lei TT, Chen C, Chen H, Xu Z, Li HH, Huang HY, Zhang F, Xu HY, Li N, Zhao CF, Li S, Dong LJ, Huang YQ, Li L, Xi Y, Qi QH, Li WJ, Zhang B, Hu W, Zhang YL, Tian XJ, Jiao YZ, Liang XH, Jin J, Gao L, Zheng WM, Hao B, Liu SQ, Wang W, Yuan LP, Cao ML, McDermott J, Samudrala R, Wang J, Wong GKS, Yang HM. The genome of Oryza sativa: A history of Duplications. PLoS Biology (2005) 3(2): e38.

39. Long M, Betran E, Kevin T, Wang W. 2003. Origin of new genes: Glimpses from the young and old. Nature Reviews Genetics (2003)4: 856-875.

40. Wyckoff G, Wang W, Wu CI. 2000. Rapid evolution of male reproductive genes in the descent of man. Nature (2000). 403: 304-309.

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